To characterize the clinical manifestations, and histologic features of CNS lymphoma in immunocompetent patients, we collected 15 cases of biopsy provedn primary CNS lymphoma.
Evidences of systemic lymphoma, HIV infection. and immune-compromising diseases were absent at the diagnosis. Brain MRI had been taken before radiation or chemotherapy, and pathologic specimens were classified according to working formulation and
some
cases underwent immunological marker studies. Mean duration of illness was 1.8 months, mild CSF protein elevation (mean=58mg%) was observed in 5 of 6 patients, CSF cytology was positive in 2 of 7, and the recurrence rate was 69%. In MR imaging,
tumor
size was variable, and 5 patients had multiple lesions at diagnosis. All patients secondary tumor change was shown in 1 case. the tumor had high tendency in abutting on CSF space (60%), and there was no relationship between histologic types and
MR
imagings. Classified by working formulation, the intermediate grade iymphomas (diffuse large cell and smll cell cleaved types) were 14 out of 15 (93%) and 1 showed low grade (small lymphocytic). B-cell lymphoma was 8 out of 9, and T-cell was only
1. As
compared with the previous reported pathologic data of AIDS-related CNS lymphoma, the histology of lymphoma in immunocompetent patients were less malignant than those related to AIDS and immune-compromised patients.
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